Valery ElaginaMorozovskaya Children Clinical Hospital of Moscow, Russia
Title: Interleukin profile in children with acute bronchiolitis
Study Objective: To find out the cytokine profile in blood serum of children with acute bronchiolitis.
Study Design: Comparative study. Materials and Methods. We examined 52 patients aged 1 to 12 months who were hospitalised to Pulmonary Department with acute bronchiolitis and respiratory distress of various severity. All children had interleukins (IL) 4, 6, and 18 in their blood measured.
Study Results. Patients demonstrated some trends in changes in their cytokine profile changes depending on respiratory distress severity. We have found direct correlations between high IL-18 levels and respiratory distress (r = 0.86), and between a history of allergies and high IL-4 levels (r = 0.78). Patients with rhinovirus had higher IL-6 values at any respiratory distress severity vs children with rhinosyncytial viral infection, who had higher IL-18 level.
Conclusion. Acute bronchiolitis is characterised by a clear pattern of interleukin expression depending on presence of confounding factors impacting the course of disease and respiratory distress severity. Patients with bronchiolitis had marked changes in their cytokine profile depending on respiratory distress severity: increased IL-18 concentration and reduced IL-4 levels. Such changes in interleukin concentrations can be used as markers in forecasting the course of pathological process.
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