Santhosh Kumar M
JSS Medical College, IndiaTitle: A prospective study of thyroid profile in children aged 1 month to 12 years of age with newly diagnosed seizure disorder started on first line antiepileptic drugs
Abstract
Background: The study's primary aim was to determine the variation in the thyroid profile status in children with newly diagnosed seizure disorders started on first-line antiepileptic drugs. In addition, this study compares the incidence of hypothyroidism secondary to phenytoin, phenobarbitone, valproate and carbamazepine.
Methods: A total of 60 children with newly diagnosed seizure disorders belonging to the age group of 1 month to 12 years were enrolled in the study. The children were subjected to a detailed history and neurological examination, and serum levels of T3, T4, and thyroid-stimulating hormone (TSH) were tested.
Results: In this study, out of 60 children, the clinical signs and symptoms of hypothyroidism were present only in one subject (1.7%), and the remaining 59 had no signs and symptoms of hypothyroidism. The mean TSH value increased from baseline 1.62±1.17 to 3 months 2.2±1.38 and 6 months 2.78±149 (p value<0.05%). The incidence of subclinical hypothyroidism among the phenytoin group (n=33) was 6.06%. Among the sodium valproate group (n=23), the incidence was 8.6%, and among the carbamazepine group (n=4), the incidence was 25%.
Conclusions: Antiepileptic drugs can alter thyroid function tests. In this study, there was no overt hypothyroidism noted. But subclinical hypothyroidism was reported in subjects using phenytoin, valproate and carbamazepine.
Biography
Santhosh Kumar M working at JSS Medical College as Associate Professor / Consultant Paediatrician since 2011. He has completed Undergraduate & Postgraduation degrees from reputed Institutes with good outcomes (MBBS from JJM Medical College, DCH from MMCRI, Mysuru and DNB from National Board of Examination New Delhi). After completing the qualification, he successfully managed many sick neonates, infants, and children in this Institute. He has attended many National & International conferences with updates of the latest knowledge about the specialty. His field of special interest is Neonatal & Endocrinology. Currently guiding postgraduate students of Paediatrics in JSS Medical College & Hospital. Has published many original Research articles and case reports in various National & International Journals.
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