Olga B Gordeeva

Russian Scientific Center of Surgery named after Academician B. V. Petrovsky, Russia

Title: Study of polymorphisms in genes coagulations at children with different nosologies

Abstract

Were examined 253 patients (from 4 months to 18 years) with different diseases (pathology of cardiovascular system, nervous system, connective tissue dysplasia, patients with hereditary monogenic syndromes). Were studied some polymorphisms in coagulation genes. It was determined that polymorphisms were more frequent in SERPINE1/PAI-1 plasminogen activator inhibitor 675, 5G>4G gene - 73.1% of all children. Leiden mutation (in heterozygous) was detected in 1.6% cases of all patients (two patients had a history of deep vein thrombosis (DVT). At the same time, polymorphisms in the VII factor R353QG>A gene, which plays a protective role against the realization of thrombotic events, were not detected in them. The dependence of polymorphisms in coagulations genes from the disease was not confirmed at this stage of work (p>0.05).

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2nd International Conference on Pediatrics and Healthcare

Olga B Gordeeva

Title: Study of polymorphisms in genes coagulations at children with different nosologies

Abstract

Biography

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