Introduction: Increased protein and energy requirements, a high level of inflammatory response, osteopenia, and endogenous intoxication syndrome in patients with cerebral palsy determine the need to use therapeutic enteral mixtures with a metabolic orientation in their diet.

Goal. To evaluate the clinical efficacy and tolerability of the use of domestic therapeutic nutrition (nutritional support) – enteral mixtures with a metabolic orientation, such as a protein detoxifying NUTRIENT cocktail and a bone tissue cocktail (protein) in children with cerebral palsy.

Materials and methods: A comparative prospective study was performed on the basis of the state autonomous healthcare institution of the children's medical rehabilitation center "Nadezhda". 39 children with cerebral palsy aged 3 to 18 years with severe motor disorders GMFCS III-V were observed. All patients were divided into 4 groups depending on age and nutritional support: main group 1 – (n = 5) age 3-8 years with eating disorders; control group 1 – (n = 5) without NP; main group 2 - (n = 21) age 9-17 years with disorders nutrition; 2nd control (n = 8) – without eating disorders. The study period was 30 days. Before and after the study, the children's general condition, nutritional status, anthropometry, densitometry, as well as blood parameters and markers of inflammation and intoxication were assessed.

Results: Against the background of nutritional support, there was a statistically significant increase in body weight, height, and z-score of body weight, mainly due to musculoskeletal mass; an increase in protein and albumin levels in the blood; a decrease in markers of intoxication and inflammation; and an increase in bone mineral density. There was an improvement in the quality of life of children, including an improvement in their motor abilities.

Conclusions: The use of domestic therapeutic nutrition, A protein detoxification cocktail, and a Cocktail for bone tissue (protein) in the diet therapy of children with cerebral palsy is effective for correcting their nutritional status, preventing the development of osteopenia, reducing inflammation and intoxication, and improving the quality of life.

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