Virtual Conference
Vered Schichter Konfino

Vered Schichter Konfino

Hillel Yale Medical Center, Israel

Title: Serum sickness reaction post MMRV vaccination in pediatric patient


Serum sickness is an immune-complex-mediated hypersensitivity reaction that classically presents with fever, rash, polyarthritis or poly arthralgias. Damage is caused by formation or deposition of antigen-antibody complexes in vessels or tissue. Deposition of immune complexes causes complement activation and/or recruitment of neutrophils by interaction of immune complexes with Fc IgG receptors.  It was first recognized as an entity in the early 1900s in patients who had received heterologous antisera, which was historically used to treat infectious diseases. The symptoms typically occur one to two weeks after exposure to an offending agent and resolve within several weeks of discontinuation.

The Mumps Measles Rubella (MMR) vaccine, introduced in the USA in 1971. It protects against three major diseases: measles, mumps, and rubella. All three of these diseases can cause serious health complications. In rare cases, they can even lead to death. It is given to all children in two doses, the first one at one year old and second dose at 6 years old. Possible side effects of the vaccination as any vaccine include Local side effects: redness, swelling and pain at the injection site. There are no known reports on cases of serum sickness after Mumps Measles Rubella Varicella (MMRV) vaccination at all.

We present a case of a one-year-old girl with serum sickness reaction one week after receiving her MMRV vaccination.