Tetiana Holovko

V. N. Karazin Kharkiv National University, Ukraine

Title: Morphofunctional features of the right ventricle of the heart in children with juvenile idiopathic arthritis

Abstract

The aim of the study: to determine the morphofunctional features of the right ventricle of the heart in adolescents with juvenile idiopathic arthritis (JIA).

Materials and methods: 91 adolescents with polyarticular variant of JIA aged 10-18 years (12.82 ± 0.33), 29 boys and 62 girls were examined. All patients received basic therapy with methotrexate for more than 12 months. The control group consisted of 45 of their peers (14.74 ± 0.32 years), 27 boys and 18 girls. An ultrasound examination was carried out on a LOGIO V2 General Electric (USA) device, with a 3Sc-RS sensor in M- and B-modes. Structural (end-systolic size (ESSrv) and volume (ESVrv), end-diastolic size (EDSrv) and volume (EDVrv), myocardial thickness (MTrv) and functional (ejection fraction (EFrv), stroke volume (SVrv) and minute volume (MVrv) indicators of the right ventricle of the heart, as well as heart rate (HR), were detected. Statistical processing of the obtained data was carried out using the SPSS17 application software package (license 4?180844250981ae3dae-s/nSPSS17) on an IBM PC/Pentium-4.

Results: in patients with JIA, a significant increase in ESSrv (2.36 ± 0.08 cm vs 1,35 ± 0,03 cm in the control group, p < 0.001) and EDSrv (2,39 ± 0,05 cm vs 2.02 ± 0.05 cm in the control group, p < 0.001). Corresponding changes also occurred in the volumetric characteristics: increased ESVrv (19.65 ± 1.50 ml vs 5.99 ± 0.70 ml in the control group, p < 0.001) and EDVrv (30.26 ± 2.05 ml vs 13,98 ± 1.11 ml of the control group, p < 0.001). At the same time, the functional parameters of the right ventricle of the heart did not change unequivocally, namely: EF was significantly lower in adolescents with arthritis (42.18 ± 1.53 % vs 58.51 ± 1.77% of the control group, p < 0.001), and stroke and minute volumes are significantly higher (SV 14.33 ± 1.47 ml vs 7.80 ± 0.51 ml in the control group, p < 0.001; MV 1.12 ± 0.12 l/min vs 0.51 ± 0, 03 l/min in the control group, p < 0.001). These changes were accompanied by significantly higher heart rate (78.41 ± 1.19 beats/min vs 66.61 ± 1.65 beats/min, p < 0.001).

Thus, in adolescents with juvenile idiopathic arthritis, an increase in both systolic and diastolic parameters of the right ventricle of the heart was found, which was accompanied by a decrease in ejection fraction and an increase in stroke volume against the background of higher heart rate and minute volume. Such changes may indicate the restructuring of the myocardium of the heart to maintain its functional state.

Biography

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INTERNATIONAL CONFERENCE ON PEDIATRICS AND HEALTHCARE

(HYBRID EVENT) | MAY 22-23, 2023 | DUBAI, UAE

Tetiana Holovko

Title: Morphofunctional features of the right ventricle of the heart in children with juvenile idiopathic arthritis

Abstract

Biography

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