Soontaree SrikosaiRajanagarindra Institute of Child Development Department of Mental Health, Thailand
Title: The link between alcohol, tobacco, and substance use during pregnancy and children’s autism spectrum disorder and attention deficit/hyperactivity disorder
Objective: To examine the relationship between maternal alcohol use, tobacco use, and substance use, and personal risks during pregnancy and children’s autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD).
Methods: A matched case-control study was conducted among 20- to 48-year-old mothers of 4 to 12-year-old children with and without ASD and ADHD. Participants were selected by stratified sampling in Chiang Mai and Lamphun Province. Questionnaires included socio-demographics of the child and mother, prenatal risks, and the alcohol, smoking, and substance involvement screening test (ASSIST). Data were analyzed using descriptive statistics, chi-square test, independent t-test, and multivariate logistic regression.
Results: A total of 432 mothers participated in the study, including 108 mothers of ASD children, 108 mothers of ADHD children, and 216 mothers of normal children. Mothers of ASD children were more likely than controls to report taking antipyretic/analgesic (AOR = 6.19, 95% CI = 1.39 - 27.54) and using of non-medical injections (AOR = 11.69, 95% CI = 1.52 - 89.91). Mothers of ADHD children were more likely than controls to report consuming alcohol at moderate risk or higher (AOR = 14.21, 95% CI = 1.06 - 190.29), smoking at moderate risk or higher (AOR = 2.97, 95% CI = 1.18 - 7.43), being exposed to secondhand smoke during the first 3 months of pregnancy (AOR = 2.63, 95% CI = 1.23 - 5.62), and using non-medical injections (AOR = 10.37, 95% CI = 1.11 - 96.33).
Conclusion: Findings can be used to promote mental health literacy and preventive interventions for reproductive women to raise awareness of the risks of having ASD and ADHD children and refrain from their own risky behaviors.
Will be updated soon.