Shankhaneel GhoshInstitute of Medical Sciences, India
Title: Late-onset group B streptococcal disease: Etiology, diagnosis, and management
GBS, also known as Streptococcus agalactiae, is a Gram-positive b-hemolytic bacterium that is a leading cause of neonatal sepsis, pneumonia, and meningitis globally. It is commonly found in the genital tract of pregnant females, causing a high probability of transmission to the neonate. Due to the global use of intrapartum antibiotic prophylaxis, rates of GBS early-onset disease have decreased; however, late-onset infections (LOGBS) are still a typical presentation of neonatal GBS disease. Although, the exact pathophysiology, transmission mode, and risk factors in children aged 7 to 89 days (late-onset disease - LOD group) remain unknown, hampering practical prevention efforts.
In this review, we looked into the aetiology, disease pathogenesis, associated complications, and therapeutic approaches concerning Late-Onset Group B Streptococcal Disease in neonates. Standard key electronic databases, a controlled vocabulary, and trial indexing were used to evaluate the pertinent studies in the public domain. These databases included PubMed, Embase, Scopus, and Cochrane Central Register of Controlled Trials (CENTRAL). Peer-reviewed studies in all languages were considered until December 2022. The following search strings and Medical Subject Heading (MeSH) terms were used: "Late Onset Group B Streptococcal Disease, "GBS" "Streptococcus agalactiae," and "Group B Streptococcal Disease".
Shankhaneel Ghosh is a 3rd year medical student from India. He is an aspiring medical researcher who enjoys connecting the dots: be it ideas from different disciplines, people from different teams, or applications from different industries. He has strong technical skills and an academic background in bioethics, biostatistics, medical coding, and academic writing. He has over 10 Pubmed indexed publications that have been cited over 20 times. He has been serving as an editorial board member of several reputed student journals.