Virtual Conference
Safina Elena Valentinovna

Safina Elena Valentinovna

Ural State Medical University, Russia

Title: Predictors of the kidney pathology development in young children


Rationale: The early onset of nephropathies poses a risk of premature kidney function loss.

The aim of the study was to evaluate the influence of ontogeny factors on the formation of nephropathies in young children.

Methods: Conducted a cohort study in 2018-2021. The main group included 69 children aged 0 to 36 months with pathological changes of ultrasound examination of the kidneys and/or urinary syndrome (leukocyturia, proteinuria, etc.). The comparison group consisted of 35 healthy children of the same age. In the studied groups, analysis of the antenatal and postnatal anamnesis was carried out, and a comparison of the morphometric urinary system parameters during neonatal ultrasound screening. In children with nephropathies, onset of the pathological process was considered. 

Results: In children with early onset of nephropathy, possible predictors of pathology are: 
1) maternal diseases: damage to the urinary system (OR = 4.99), cardiovascular system (OR = 10.26), genital tract inflammation (OR = 10.61); anemia (OR = 6.94); 
2) pathology of pregnancy: gestational diabetes (OR = 7.24), preeclampsia (OR = 4.40), pathology of the placenta (OR = 17.0) and fetoplacental insufficiency (OR = 7.61); 
3) early transfer to milk formulas (OR = 2.81). 

According to ultrasound data, in this group, already in the first months of life, 50.7% of children have persistent urodynamic disorders, and signs of kidney parenchymal edema. ?he inflammatory process manifestation against the background of a burdened perinatal history and congenital malformations occurs earlier – at 2 months, and without malformations – at 4 months (p = 0.004).

Conclusion: A burdened antenatal and neonatal history has a negative impact on the morphogenesis of the organs of the urinary system, creating conditions for the early formation of nephropathies already in the first months of life.


Safina Elena Valentinovna is a ?ssistant ?rofessor, author and co-author of 35 scientific papers, including: "Epidemiology and dynamics of the morbidity of the genitourinary system in children of the Sverdlovsk region and the city of Yekaterinburg", "Nephropathy in young children, factors of their early implementation", "Clinical features of the course of urinary tract infections in children early age”, “Nephropathy in young children: hemodynamic features”. The main scientific interests are the problems of nephrology, pathology of young children. She has 7 years of teaching experience. Conducts practical classes for students of 3 and 4 courses. Author and co-author of 12 teaching materials for students, interns, residents and doctors. Co-author of the article "Formation of professional competencies at the Department of Children's Diseases of the Faculty of Medicine" in the Bulletin of the Ural State Medical University (2018).