Phuong Thi NguyenThai Nguyen University of Pharmacy and Medicine, Vietnam
Title: Growth patterns of preterm infants and small for gestational age children during the first 10 years of life
Background: Preterm and small for gestational age (SGA) remain significant public health concerns worldwide. Yet limited evidence exists on their growth patterns during childhood from low-or middle-income countries.
Objectives: We investigated the postnatal growth patterns of preterm and SGA compared to term appropriate for gestational age (AGA) children from birth to 10–11y, and examined the impact of birth status on child nutritional status during the school age years.
Methods: Children born to women who participated in a double-blinded randomized controlled trial of preconception micronutrient supplementation in Vietnam were classified into 3 groups: preterm AGA (n = 130), full-term SGA (n = 165) and full-term AGA (n= 1072). Anthropometric data (weight and height) were collected prospectively at birth, 3, 6, 12, 18, 24 months and at 6-7 and 10-11y. We used ANOVA and multiple regression models to examine the differences in growth patterns from birth to 10-11y as well as child undernutrition and overnutrition by birth status.
Results: Children who were born preterm exhibited rapid postnatal growth, but still had lower WAZ and HAZ at 1y and 2y and showed catch up to the AGA group at 6y. Compared to the AGA group, SGA children had lower WAZ, HAZ, BMIZ and were 2-3 times more likely to be undernourished in all periods; these differences however got smaller when children were older. No associations were found between preterm or SGA and overweight /obesity at age 10-11y.
Conclusions: Children who were born term-SGA continued to demonstrate deficits in weight and height during childhood whereas those born preterm showed catch-up growth by age 6-7y. There were no differences in the prevalence of overweight/obesity by birth size and prematurity.
Will be updated soon.