Pathak Shweta
NSCB Medical College Jabalpur, IndiaTitle: Nutritional status in paediatric patients with acute leukaemia during induction chemotherapy: A retrospective analysis from a tertiary care centre in central India
Abstract
Background: Acute Leukemia in children is a potentially curable disease and its prognosis has been linked to several factors, such as nutritional status. Malnutrition is present in 44% patients at diagnosis, this increased to 46% in pediatric cancer patients post induction1. Under nutrition among pediatric acute leukemia patients is more in developing countries 60% as compared to 10% in developed countries 2,3. A retrospective cohort study of 41 children with a recent diagnosis of Lymphoid or myeloid malignancy was done to determine the frequency of malnutrition before and after induction chemotherapy and outcome of ALL postinduction. Children with malnutrition at the time of diagnosis are more prone to have frequent episodes of febrile neutropenia which makes them prone for having prolonged hospitalization and increased risk of mortality.
Methods: A retrospective cohort study of 41 children with a recent diagnosis of Lymphoid or myeloid malignancy was done to determine the frequency of malnutrition before and after induction chemotherapy and outcome of ALL postinduction.
Conclusion: Children with malnutrition had significantly more episodes of febrile neutropenia as compare to those with adequate nutrition. Four children died during induction period and cause of death was infectious illness. All the children who died had severe malnutrition.
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