Jun WangLoma Linda University, USA
Title: Relationship of Post-Transplant Lymphoproliferative Disorders (PTLD) subtypes and clinical outcome in pediatric heart transplant recipients: A retrospective single institutional analysis of 558 patients
Post-Transplant Lymphoproliferative Disorders (PTLD) are heterogenous lymphoproliferative disorders that develop as a consequence of immunosuppression in transplant recipients. We performed a retrospective review of PTLD occurring in pediatric heart transplant recipients. A total of 558 children and infants underwent cardiac transplantation at our institution between 1985 and 2019 were followed until March 2021. Forty-nine of 558 patients developed PTLD (8.8%). As compared to older children (>1 year of age), infant recipients (<3 months of age) were less likely to develop PTLD. Monomorphic PTLDs (M-PTLD, 61%) was the most common subtype at initial diagnosis, followed by non-destructive (21%), polymorphic (14%), and classic Hodgkin lymphoma (cHL, 4%). Patients who underwent transplantation at a young age (<3 months) had significantly lower rates of M-PTLD or cHL, and longer time from transplant to PTLD diagnosis as compared to children older than 1 year at transplant (p=0.04). Tthose patients with a shorter time to PTLD diagnosis showed a trend toward a higher rate of M-PTLD or cHL. As expected, the overall survival (OS) of patients with M-PTLD or cHL was significantly lower than patients with non-destructive or polymorphic PTLD.
Jun Wang completed his medical degree from Wannan Medical College in 1982 and M.S. degree in immunology from Zhejiang Academy of Medical Sciences in 1985 in China. Jun Wang completed postdoctoral research training while holding the World Health Organization (WHO) Fellowship Award at University of Southern California (USC) School of Medicine (1989-1990) and the Will Rogers Memorial Foundation Fellowship Award at UCLA School of Medicine (1991-1994). Jun Wang completed his Pathology Residency training (1995-1999) at UCLA-Harbor Medical Center, University of California Los Angeles (UCLA) School of Medicine in 1999, as well as his Surgical Pathology Fellowship and Hematopathology Fellowship training at the City of Hope National Medical Center in 2000 and 2001 in USA. Jun Wang is the Chief of the Hematopathology Section at the Department of Pathology and Laboratory Medicine, Loma Linda University Medical Center, and a Full Professor of Pathology & Human Anatomy at Loma Linda University School of Medicine.