Virtual Conference
Daria Yartseva

Daria Yartseva

Zaporizhzhia State Medical University, Ukraine

Title: Algorithm testing of recurrent and chronic urticaria diagnostics in children


The question about autoimmune etiology of chronic spontaneous urticaria (CSU) is discussing last years, however routine high-specific diagnostic tests for confirmation of this hypothesis are absent.

The aim of our investigation was to test diagnostic algorithm, designed by us. Peculiarity of this algorithm is using of available for routine clinical practice methods only.

Category of patients: There are 13 children with complains of itchy urticarial rush lasting over 6 weeks without any visible cause were involved in the study. Children have been diagnose with CSU. Age of children was in range of 2-17 y.o.

There are next methods were performed: clinical, anamnestic, prick-testing with different allergens, tests for physical urticaria, autoserum skin test (ASST), ultrasound examination. There are lab methods were performed: CBC, biochemical tests, detection of helminths, common and specific IgE, detection of autoantibodies level.

Results: ASST was positive in 75% of Pts. Tests for physical urticaria: aquagenic, vibrational, cold, heat tests were negative in 100% of children; dermographic and test with physical exertion were positive in 22,2%. Level of IgE was in normal range in 2/3 of investigated children. We have examined our Pts of thyroid pathology presence. It was found that 61,5% of children has ultrasound confirmation of autoimmune diffuse parenchymal changes in thyroid gland. In 1/3 of them were detected antithyroid autoantibodies, and only 2 of them has impairment of the function. Children, who hasn’t ultrasound changes, were examined of ANA level. In 40% of these ANA level was increased. Generally, among 13 examined children the signs of autoimmune process has been find in 12 (92,3%) patients.

Summary: The data suggested hypothesis that CSU is a part of systemic autoimmune answer and immunocompetent cells of the skin are shock organ. Results of this work suggested necessity of further investigations.


Daria Yartseva has completed her PHD in 2011 from Zaporizhzhia State Medical University, Ukraine. She is associate professor in ZSMU, pediatrician, allergist in Municipal Children’s hospital, physician-coordinator of the South-East region of Ukraine on questions of HAE. The fields of scientific interest are urticaria and angioedema (hereditary and aquired).