Virtual Conference
Anet Papazovska Cherepnalkovski

Anet Papazovska Cherepnalkovski

University of Split, Croatia

Title: White matter injuries of prematurity


White matter lesions of prematurity, formerly known as periventricular leukomalacia (PVL), are the leading cause of cerebral palsy and other neurocognitive deficits in premature infants. They most often occur in premature infants < 32 weeks of gestation. Indisputable risk factors are perinatal hypoxia-ischemia and infection-inflammation as well as their combined impact. Clinical manifestations vary depending on the type of injury. There are three types of pathoanatomical damage to the white matter: macroscopic cystic, microscopic cystic and diffuse (non-cystic), each presenting with a specific clinicopathologic correlate. Due to the advances in neonatal intensive care medicine, diffuse non-cystic damage is becoming the most common white matter lesion in preterm infants. These changes are more likely to contribute to cognitive and behavioral disorders than to motor disorders in contemporary groups of preterm infants. Diagnostic workup consists of serial brain ultrasound scans or brain magnetic resonance imaging, each with certain advantages and limitations. Recent studies have focused on finding new therapeutic methods and prenatal biochemical markers of early brain injury. This presentation reviews current literature data on the topic of white matter injuries in prematurity with emphasis on the pathophysiology, diagnosis, and management of these injuries. The presentation also contains the author's photographic and clinical material.


Anet Papazovska Cherepnalkovski has completed her PhD at the University of Skopje, Republic of North Macedonia in 2016. She has worked as Head of Department for preterm birth from 2013-2015 and Head of Clinical Department of neonatology at the Pediatric Clinic in Skopje, before transferring to work as an intensive care neonatologist at University Hospital of Split, Croatia. She has been involved in education of medical students and pediatric residents since 2008 both in N. Macedonia and Croatia and promoted into assistant professor in 2020. She has been assigned head of three and associate on one undergraduate courses at the Department for midwifery. She has over 90 publications, and her publication h-index is 2. She has been lecturing two continuous medical education courses in Croatia and one CME course in North Macedonia. She has collaborated on 3 scientific research projects and has been serving as an editorial board member of several reputed journals.